r0ttenways:

Hahahaa odb.

r0ttenways:

Hahahaa odb.

(Source: gonjasensai, via blind-threats)

@2 hours ago with 23482 notes

(Source: eezydeezy, via hip-hop-influence)

@1 day ago with 159 note and 746 play

(Source: foxontherun, via patternbase)

@1 day ago with 244 notes
@2 days ago with 2163 note and 9031 play

galasai:

Lucian Bran

Promised Land, 2012

(via villenoire)

@2 days ago with 3247 notes
paintdeath:

Paul Blow: Independent

paintdeath:

Paul Blow: Independent

(via herohopes)

@2 days ago with 3621 notes
currentsinbiology:

cestpapillon:

krampuslips:

foxes are the most important animals on earth

im going to keep reblogging this until it isn’t cute anymore

I am afraid it will never be not cute….

currentsinbiology:

cestpapillon:

krampuslips:

foxes are the most important animals on earth

im going to keep reblogging this until it isn’t cute anymore

I am afraid it will never be not cute….

(Source: cineraria)

@2 days ago with 911778 notes
currentsinbiology:

Total darkness at night key to success of breast cancer therapy
Exposure to light at night, which shuts off nighttime production of the hormone melatonin, renders breast cancer completely resistant to tamoxifen, a widely used breast cancer drug, says a new study by Tulane University School of Medicine cancer researchers. The study, “Circadian and Melatonin Disruption by Exposure to Light at Night Drives Intrinsic Resistance to Tamoxifen Therapy in Breast Cancer,” published in the journal Cancer Research, is the first to show that melatonin is vital to the success of tamoxifen in treating breast cancer!

"High melatonin levels at night put breast cancer cells to ‘sleep’ by turning off key growth mechanisms. These cells are vulnerable to tamoxifen. But when the lights are on and melatonin is suppressed, breast cancer cells ‘wake up’ and ignore tamoxifen," Blask says.


Robert T. Dauchy et al. Circadian and Melatonin Disruption by Exposure to Light at Night Drives Intrinsic Resistance to Tamoxifen Therapy in Breast Cancer. Cancer Research, July 2014 DOI: 10.1158/0008-5472.CAN-13-3156

currentsinbiology:

Total darkness at night key to success of breast cancer therapy

Exposure to light at night, which shuts off nighttime production of the hormone melatonin, renders breast cancer completely resistant to tamoxifen, a widely used breast cancer drug, says a new study by Tulane University School of Medicine cancer researchers. The study, “Circadian and Melatonin Disruption by Exposure to Light at Night Drives Intrinsic Resistance to Tamoxifen Therapy in Breast Cancer,” published in the journal Cancer Research, is the first to show that melatonin is vital to the success of tamoxifen in treating breast cancer!

"High melatonin levels at night put breast cancer cells to ‘sleep’ by turning off key growth mechanisms. These cells are vulnerable to tamoxifen. But when the lights are on and melatonin is suppressed, breast cancer cells ‘wake up’ and ignore tamoxifen," Blask says.

Robert T. Dauchy et al. Circadian and Melatonin Disruption by Exposure to Light at Night Drives Intrinsic Resistance to Tamoxifen Therapy in Breast Cancer. Cancer Research, July 2014 DOI: 10.1158/0008-5472.CAN-13-3156

@2 days ago with 171 notes
yungbasedbae:

yungmermayd:

babygirl

damn ma

yungbasedbae:

yungmermayd:

babygirl

damn ma

(via hip-hop-school)

@1 day ago with 17609 notes
goodlife-fashion-music-art-lux:

Good Life. | FASHION | MUSIC | WORLD | LUXURY | ART And much more.
@1 day ago with 389 notes

(Source: jellyequalsgerm, via cockbarf)

@1 day ago with 8682 notes
pyramaze:

David Hardy

pyramaze:

David Hardy

(via empyr3an)

@2 days ago with 3742 notes
buingu:

原田ちあき
@2 days ago with 1915 notes

(Source: victortattoo, via villenoire)

@2 days ago with 63589 notes
currentsinbiology:

biomorphosis:

Mudskipper is a fish which spend more time on land than in water. In fact, a mudskipper will drown if it’s never able to reach the water’s surface! Like other fish, mudskippers breathe through gills, but in addition they absorb oxygen through their skin and the linings of their mouths and throats. They are able to move over land by using their pectoral fins to pull themselves forward, or they perform a series of skips or jumps. Pokemon “Mudkip” is based on this fish.

And what about those funky eyes??

currentsinbiology:

biomorphosis:

Mudskipper is a fish which spend more time on land than in water. In fact, a mudskipper will drown if it’s never able to reach the water’s surface! Like other fish, mudskippers breathe through gills, but in addition they absorb oxygen through their skin and the linings of their mouths and throats. They are able to move over land by using their pectoral fins to pull themselves forward, or they perform a series of skips or jumps. Pokemon “Mudkip” is based on this fish.

And what about those funky eyes??

@2 days ago with 5771 notes